Discovery of enhanced bone growth could lead to new treatments for osteoporosis

UCLA and UC San Francisco life scientists have discovered a dramatic pattern of bone growth in female mice—research that could potentially lead to stronger bone density in women and new treatments for osteoporosis in older women. The researchers found that blocking a particular set of signals from a small number of neurons in the brain causes female, but not male, […]

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Engineered immune cells target broad range of pediatric solid tumors in mice

Immune cells engineered to attack childhood cancers were able to eradicate different types of pediatric tumors in mice, according to a new study from the Stanford University School of Medicine. The study, which will be published online Jan. 17 in Clinical Cancer Research, provides evidence that these engineered cells can target many types of pediatric solid tumors, including brain tumors. […]

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New yeast model of metabolic disorders may lead to life-saving therapies

There are hundreds of metabolic disorders—including phenylketonuria, tyrosinemia, maple syrup urine disease and homocystinuria. These disorders lead to congenital diseases that produce a critical enzyme deficiency that interferes with the body’s metabolism. The pathologies and symptoms vary among the diseases, but all of them are usually fatal and have no known cure. Most metabolic disorders affect infants. The majority of […]

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Scientists make strides in creation of clinical-grade bone

A team of scientists from the New York Stem Cell Foundation (NYSCF) Research Institute reported Friday in Stem Cell Research and Therapy that they have made valuable progress toward creating clinical-grade cells for treatment of bone disease and injury. In their study, the team identified two types of growth media that could support effective expansion of mesenchymal progenitor (MP) cells […]

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Protective effects of ADM-RAMP2 system make it a new therapeutic target for retinal vein occlusion

A clot in the retinal vein can lead to severe and irreversible loss of vision. In a report in the American Journal of Pathology investigators utilize a newly developed model of central retinal vein occlusion (CRVO) in mice that mimics many of the clinical features of CRVO in humans to study the pathologic effects of retinal occlusion and demonstrate the […]

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Mel B Says She Had Her Vagina ‘Scraped’ to Remove Traces of Her Ex

Spice Girl Mel B recently revealed that she had the inside of her vagina “scraped” to get rid of all traces of her ex-husband, Stephen Belafonte. If that term makes you clench your legs, you’re not alone. Now, ob-gyns everywhere are taking to the internet to tell women to never, ever have their vagina scraped…seriously, never.  In a December interview with The Guardian to […]

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Exploration of umbelliferone based derivatives as potent MAO inhibitors

Monoamine oxidase (MAO) inhibitors are potential drug candidates for treating neurological disorders such as anxiety, Alzheimer’s disease and Parkinson’s disease. This review presents information about MAO inhibitory effects of the umbelliferone based derivatives. The potential antioxidant effects of the derivatives were evaluated by DPPH and H2O2 scavenging methods. The derivatives were screened for hMAO-A and hMAO-B inhibition through a series […]

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Rob Delaney Reveals Birth of Fourth Child — 7 Months After Death of Son

Catastrophe actor Rob Delaney and his wife, Leah, recently revealed that they welcomed their fourth child — a son — in August, only seven months after the devastating loss of their 2-year-old, Henry, who died from brain cancer. This December, Delaney told the U.K.’s The Sunday Times Magazine, “We likely would’ve had a fourth anyway. But I mean, there’s mixed feelings. It’s […]

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FDA approves drugs for treatment of two rare blood diseases

(HealthDay)—Two drugs have been approved by the U.S. Food and Drug Administration for the treatment of rare blood diseases, the agency announced Friday. Elzonris (tagraxofusp-erzs) infusion was granted the first approval for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and children aged 2 years and older. Researchers investigated the efficacy of Elzonris in two patient cohorts […]

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