New treatment strategy exploits acquired vulnerability in drug-resistant melanoma

Cancer cells that develop resistance to drugs pay a price for this by simultaneously developing a new vulnerability. If this acquired vulnerability can be identified, it may be exploited clinically. A team of cancer researchers, led by Rene Bernards of the Netherlands Cancer Institute and Oncode Institute, have now exposed this acquired vulnerability in melanoma that has developed resistance to […]

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New research puts distinct memories of similar events in their place

Neuroscientists have found new evidence on how distinct memories of similar events are represented in the brain. Its findings, which appear in the journal Neuron, correct a previous misconception of how such memories are stored in the hippocampus—a part of the brain crucial for memory and understanding space. “Previous research suggested that brain cells were ‘re-mapped’ in making distinctions between […]

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A new drug to help young patients with genetic obesity

In a new study, researchers from the Institute for Experimental Pediatric Endocrinology of the Charité – Universitätsmedizin Berlin have successfully treated patients whose obesity is caused by a genetic defect. Aside from its beneficial effects on the patients, the researchers also provided insights into the fundamental signaling pathways regulating satiety of the new drug. The results of this research have […]

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Scientists discover a new way to battle multiple sclerosis

Ridiculous. That’s how Andrew Caprariello says his colleagues described his theory about multiple sclerosis (MS) back when he was doing his PhD in Ohio. Caprariello’s passion to explore controversial new theories about MS propelled him to seek out a postdoctoral fellowship with a like-minded thinker, whom he found in University of Calgary’s Dr. Peter Stys, a member of the Hotchkiss […]

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Study discovers new molecular mechanism likely involved in cancer metastasis

Cancer is most devastating when it metastasizes—when tumor cells break away, travel through the bloodstream, and then attach elsewhere, only to grow another tumor. A significant amount of scientific research has focused on finding ways to prevent metastasis. For some time, scientists have understood that a particular biochemical pathway, known as the PDK1 pathway, is active in metastasizing cancer cells. […]

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Brain quickly adapts to new surroundings, only sees the most important information captured though eyes

Certain objects attract our attention in a particular way. It could be something that is especially ugly or something that we perceive as being rather pretty. With a background in design, I ought to know something about what makes one object appear prettier than another. However, you don’t have to look far before it becomes difficult to predict whether something […]

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New studies measure screen-based media use in children

A new study examines the effectiveness of the ScreenQ, a measure of screen-based media use in children. Findings from the study will be presented during the Pediatric Academic Societies (PAS) 2018 Meeting. “In a single generation, the explosion of screen-based media has transformed the experience of childhood, from TV and videos, to an unlimited range of content available at any […]

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EPO protects preemies’ brains by modifying genes essential for generating new brain cells

Erythropoietin (EPO) helps to protect and repair vulnerable brains though it remains a mystery how the anemia drug does so. Genetic analyses conducted by a multi-institutional research team finds that EPO may work its neuroprotective magic by modifying genes essential for regulating growth and development of nervous tissue as well as genes that respond to inflammation and hypoxia. Findings from […]

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New approach for treating neuropathic pain

Neuropathic pain is the chronic, pathological pain that continues even when the cause of pain is removed. Causes include damage to nerve cells and medicines used to treat cancer. A collaboration between research groups from Indiana University in Bloomington, USA and Turku Centre for Biotechnology in Finland has discovered a novel therapeutic that appears to interrupt the signaling cascades in […]

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