Model predicts bat species with the potential to spread deadly Nipah virus in India

Since its discovery in 1999, Nipah virus has been reported almost yearly in Southeast Asia, with Bangladesh and India being the hardest hit. In a new study, published today in PLoS Neglected Tropical Diseases, scientists used machine learning to identify bat species with the potential to host Nipah virus, with a focus on India—the site of a 2018 outbreak. Four […]

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Human-on-a-chip model tests cancer drug efficacy and toxicity for therapeutic index

A reconfigurable “body-on-a-chip” model could transform drug development by simultaneously measuring compound efficacy and toxicity, for both target cells and other organs, such as the heart and liver. These findings, published in Science Translational Medicine, demonstrate the ability of a body-on-a-chip model to truly revolutionize biomedical research and personalized medicine through more accurate and efficient preclinical testing without the use […]

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Broken brain cells repaired in dementia mouse model

Dysfunctional neurons in the hippocampus of adult female mice modeling dementia can be repaired and reconnected to distant parts of the brain, reports a new study published in JNeurosci. The similarity between the mouse model and the human condition underscores the therapeutic potential of targeting these cells in dementia patients. The hippocampus generates new brain cells throughout life and is […]

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Closed ICU model may reduce hospital-acquired infections

(HealthDay)—A closed intensive care unit (ICU) model, whereby a patient is evaluated and admitted under an intensivist and orders involving patient care are written by the ICU team, is associated with a reduction in certain types of hospital-acquired infections, according to a study presented at the American Thoracic Society 2019 International Conference, held from May 17 to 22 in Dallas. […]

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A new machine learning model can classify lung cancer slides at the pathologist level

Machine learning has improved dramatically in recent years and shown great promise in the field of medical image analysis. A team of research specialists at Dartmouth’s Norris Cotton Cancer Center have utilized machine learning capabilities to assist with the challenging task of grading tumor patterns and subtypes of lung adenocarcinoma, the most common form of the leading cause of cancer-related […]

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Researchers 3-D bio-print a model that could lead to improved anticancer drugs and treatments

University of Minnesota researchers have developed a way to study cancer cells which could lead to new and improved treatment. They have developed a new way to study these cells in a 3-D in vitro model (i.e. in a culture dish rather than in a human or animal). In a paper recently published in Advanced Materials, Angela Panoskaltsis-Mortari, Ph.D., Vice […]

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New yeast model of metabolic disorders may lead to life-saving therapies

There are hundreds of metabolic disorders—including phenylketonuria, tyrosinemia, maple syrup urine disease and homocystinuria. These disorders lead to congenital diseases that produce a critical enzyme deficiency that interferes with the body’s metabolism. The pathologies and symptoms vary among the diseases, but all of them are usually fatal and have no known cure. Most metabolic disorders affect infants. The majority of […]

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Genetically engineered 3-D human muscle transplant in a murine model

A growing need for tissues and organs in surgical reconstruction is addressed by the promising field of tissue engineering. For instance, muscle atrophy results from severe traumatic events including deep burns and cancer, requiring site/donor compatible surgical reconstruction. The existing ‘gold standard’ treatment in reconstructive surgery incorporates autologous flaps, although the technique is limited by low anatomical availability and donor […]

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New stem cell model can be used to test treatments for a rare nervous system disorder

A City of Hope researcher has developed a stem cell model to assess possible treatments for a rare nervous system disorder that is in the same disease group as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). The finding takes Yanhong Shi, Ph.D., senior author of the study, and her colleagues one step closer to finding a way to […]

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