Researchers 3-D bio-print a model that could lead to improved anticancer drugs and treatments

University of Minnesota researchers have developed a way to study cancer cells which could lead to new and improved treatment. They have developed a new way to study these cells in a 3-D in vitro model (i.e. in a culture dish rather than in a human or animal). In a paper recently published in Advanced Materials, Angela Panoskaltsis-Mortari, Ph.D., Vice […]

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New yeast model of metabolic disorders may lead to life-saving therapies

There are hundreds of metabolic disorders—including phenylketonuria, tyrosinemia, maple syrup urine disease and homocystinuria. These disorders lead to congenital diseases that produce a critical enzyme deficiency that interferes with the body’s metabolism. The pathologies and symptoms vary among the diseases, but all of them are usually fatal and have no known cure. Most metabolic disorders affect infants. The majority of […]

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Genetically engineered 3-D human muscle transplant in a murine model

A growing need for tissues and organs in surgical reconstruction is addressed by the promising field of tissue engineering. For instance, muscle atrophy results from severe traumatic events including deep burns and cancer, requiring site/donor compatible surgical reconstruction. The existing ‘gold standard’ treatment in reconstructive surgery incorporates autologous flaps, although the technique is limited by low anatomical availability and donor […]

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New stem cell model can be used to test treatments for a rare nervous system disorder

A City of Hope researcher has developed a stem cell model to assess possible treatments for a rare nervous system disorder that is in the same disease group as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). The finding takes Yanhong Shi, Ph.D., senior author of the study, and her colleagues one step closer to finding a way to […]

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A new model to estimate lifetime risk of atherosclerotic cardiovascular disease

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality and also contributes to huge health care expenditures in China. Therefore, accurate and early identification of high-risk individuals is important for CVD prevention. The China-PAR (Prediction for atherosclerotic CVD (ASCVD) Risk in China) project generated equations with excellent capacity to predict lifetime risk for ASCVD by incorporating four large […]

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Novel therapy delays muscle atrophy in Lou Gehrig’s disease model

Supplementing a single protein found in the spinal cord could help prevent symptoms of Lou Gehrig’s disease, according to a new study out of Case Western Reserve University School of Medicine. Researchers found high levels of the protein—called mitofusion 2 or Mfn2—prevented nerve degeneration, muscle atrophy, and paralysis in a mouse model of the disease. Since Mfn2 is often depleted […]

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Rhesus macaque model offers route to study Zika brain pathology

Rhesus macaque monkeys infected in utero with Zika virus develop similar brain pathology to human infants, according to a report by researchers at the California National Primate Research Center and School of Veterinary Medicine at the University of California, Davis, published June 20 in Nature Communications. Rhesus macaques may be a suitable model system to study how Zika virus infection […]

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Nurses outperform doctors in colorectal cancer surveillance model

Putting nurses in charge of colorectal cancer surveillance instead of doctors has shown to reduce the number of unnecessary colonoscopies and the number of cases progressing to cancer. The South Australian audit of 732 colonoscopies over three months in 2015 found that 97 per cent of procedures adhered to Australian guidelines in the nurse-led model while compliance was just 83 […]

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Downward-facing mouse: Stretching reduces tumor growth in mouse model of breast cancer

Many cancer patients seek out gentle, movement-based stretching techniques such as yoga, tai chi and qigong, but does stretching have an effect on cancer? While many animal studies have attempted to quantify the effects of exercise on the disease, results have been mixed. Furthermore, studies in animals involve levels of vigorous exercise that can be difficult for cancer patients. Investigators […]

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