Long-term memory performance depends upon gating system, study finds

Storing and retrieving memories is among the most important tasks our intricate brains must perform, yet how that happens at a molecular level remains incompletely understood. A new study from the lab of Neuroscience Professor Ronald Davis, Ph.D., at Scripps Research, Florida, sheds light on one element of that memory storage process, namely the storage and retrieval of a type […]

Continue reading »

Restoring protein homeostasis improves memory deficits in Down syndrome model

Down syndrome is the most common genetic cause of intellectual disability, and currently there is no effective treatment. Memory deficits are a hallmark of this condition and a study published today in the journal Science reports that the defects in a conserved stress pathway dubbed the ‘integrated stress response,’ or ISR, could explain the cognitive deficits in a mouse model […]

Continue reading »

Unexpectedly big wins improve two kinds of memory

Researchers have discovered that instances in which outcomes are better than expected—finding an unexpectedly good parking spot, for example, or spotting a $20 bill on the sidewalk—improves memories of specific events. This is in addition to the long-established role that unexpectedly good outcomes have in influencing what are called integrated memories. Remembering where you parked your car this morning is […]

Continue reading »

Primed for memory formation

A new study carried out in a collaboration between researchers from LMU and UC San Diego suggests that new sensory experiences are encoded in pre-existing patterns of neuronal activity, which are recalled, modulated and enhanced following periods of behavioral activity. Nerve cells located in the hippocampus and the neighboring medial entorhinal cortex (MEC) are crucial for the formation of memories, […]

Continue reading »

Scientists uncover how rare gene mutation affects brain development and memory

Researchers from the University of California, Irvine School of Medicine, have found that a rare gene mutation alters brain development in mice, impairing memory and disrupting the communication between nerve cells. They also show memory problems could be improved by transplanting a specific type of nerve cell into the brain. The findings were published today in Neuron. “Mutations in hundreds […]

Continue reading »

Virtual brain gives insights into memory deficits in depression

During a depressive episode, the ability of the brain to form new brain cells is reduced. Scientists of the Ruhr-Universität Bochum examined how this affects the memory with a computational model. It was previously known that people in an acute depressive episode were less likely to remember current events. The computational model however suggests that older memories were affected as […]

Continue reading »
1 2