Loss of function in key Y-chromosome genes increases cancer risk in men

Numerous studies have shown that men are more susceptible to cancer than women; however, the reason for this difference remains poorly understood. A new study by researchers from the Barcelona Institute for Global Health (ISGlobal) has identified a key biological mechanism that puts men at higher risk of cancer: loss of function in certain genes of the sex-determining Y chromosome. […]

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Breaking the dogma: Key cell death regulator has more than one way to get the job done

Scientists at St. Jude Children’s Research Hospital have discovered a new way that the molecule RIPK1 leads to cell death in infected, damaged or unwanted cells showing that more than one mechanism can trigger the process. The findings appeared online today in the Journal of Experimental Medicine. “Our findings break the existing dogma that RIPK1 kinase activity is required for […]

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Identification of a key protein linked to ageing

Ageing is a dramatic public health issue in the face of the current demographic changes: the proportion of 60 and over in the world’s population will almost double by 2050. In this context, a new discovery has just broadened scientific knowledge. Researchers from the Developmental and Stem Cell Biology Department at the Institut Pasteur shed light on the mechanisms of […]

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Trauma-focused therapy may hold key to reducing women’s offending

Women prisoners might benefit from female-specific treatment that addresses the traumas common among women. A new report, launched at the Houses of Parliament today, analyzes the benefits of the Healing Trauma intervention programme currently running in eight of the UK’s 12 women’s prisons. The report outlines how trauma such as sexual assault, sexual abuse and domestic abuse, which affect mostly […]

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Estrogen receptors might hold key in obesity prevention

Despite countless fad diets, both obesity and metabolic diseases continue to plague communities across the U.S. Now, researchers from the University of Missouri believe that the clue to treatment might be related to estrogen—for both men and women. In two separate studies, Vicki Vieira Potter and Jaume Padilla, researchers in the Department of Nutrition and Exercise Physiology, have found that […]

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Interaction between two immune cell types could be key to better dengue vaccines, study shows

Researchers at Duke-NUS Medical School have demonstrated for the first time a physical interaction between two types of immune cells that plays an important role in the early fight against dengue virus infection. Dengue virus is widespread in the tropics and is transmitted by mosquitos. Dengue virus infection incidence has grown dramatically in recent years, with estimates suggesting 390 million […]

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