Insulin Resistance and Parkinson's Disease

A growing pool of evidence suggests that Type 2 diabetes mellitus (T2DM) and Parkinson’s disease (PD) may share common pathological mechanisms, and that the presence of T2DM increases the risk of developing PD by 40%. Measuring blood sugar level. Image Credit: Neirfy / Shutterstock How is T2DM Connected to PD? PD, the second most common neurodegenerative disorder after Alzheimer’s disease, […]

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A common insulin signaling pathway across cancer and diabetes

An oncology researcher has made an unexpected contribution to the understanding of type 2 diabetes. In results published in Science Advances, Patrick Hu, M.D., associate professor of medicine at Vanderbilt University Medical Center, found a protein that modulates a signaling pathway often targeted by cancer therapies is also required for insulin biogenesis. Hu and colleagues showed a protein controlling the […]

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High insulin costs come under fire on Capitol Hill

(HealthDay)—For many Americans, the cost of lifesaving insulin is simply too high, leading as many as one in four to ration the drug, experts testifying before the House Committee on Energy and Commerce said this week. The meeting focused primarily on defining the problem and exploring potential solutions, such as lowering the list prices of insulin and increasing transparency so […]

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Insulin price more than doubled in the US

(HealthDay)—Some Americans with type 1 diabetes have cut back on their insulin usage as the cost of the drug nearly doubled over a five-year period. The annual amount that patients with type 1 diabetes spent on the drug rose from about $2,900 in 2012 to about $5,700 in 2016, according to a new analysis from the nonprofit Health Care Cost […]

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Insulin discovery a game-changer for improving diabetes treatments

An international collaboration co-led by researchers at the Walter and Eliza Hall Institute has made a discovery that could make therapeutic insulins more effective by better mimicking the way insulin works in the body. The findings could improve treatments for diabetes, a disease that impacts the lives of millions of people worldwide. Published today in Nature Communications, the study reveals […]

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AMA: Federal government must tackle rising insulin prices

(HealthDay)—U.S. officials need to take action to control spiking insulin prices, the American Medical Association (AMA) says. The Federal Trade Commission and the Justice Department should monitor insulin pricing and market competition and take any necessary enforcement measures, AMA members agreed at the group’s annual meeting. The nation’s largest physicians group said the rising cost of insulin is causing big […]

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Abdominal fat secretes novel adipokine promoting insulin resistance and inflammation

An international research team in which the DZD is participating has identified a novel adipokine that favors the development of insulin resistance and systemic inflammation. In cases of severe obesity, this adipokine is secreted by the adipocytes of the abdominal fat tissue and released into the bloodstream. The new findings could contribute to the development of alternative approaches for the […]

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