Study identifies protein’s role in mediating brain’s response to stress

A study led by Massachusetts General Hospital (MGH) investigators has identified a critical role for a protein called Kruppel-like factor 9 (Klf9) in the brain’s response to stress, which has implications for protecting against the effects of stress in conditions like major depression and post-traumatic stress disorder (PTSD). In their paper published in Cell Reports, the team describes finding that […]

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Obesity in childhood and adulthood shown to increase risk of knee and hip osteoarthritis

The results of a study to be presented at the Annual European Congress of Rheumatology (EULAR 2018) suggest childhood and adult obesity increase the risk of developing hip osteoarthritis (OA) and knee OA but not hand OA. Obesity and OA are two interconnected health care problems affecting a large proportion of the adult population worldwide, however studying causality in this […]

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Both quantity and quality of sleep affect cardiovascular risk factors in adolescents

A study from a research team led by a MassGeneral Hospital for Children (MGHfC) physician finds that both the quantity and quality of sleep—the amount of time spent sleeping and the percentage of sleep that is undisturbed—in young adolescents have significant effects on aspects of cardiovascular health such as blood pressure, cholesterol levels and abdominal fat deposition. Their report has […]

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Study shows how intensive instruction changes brain circuitry in struggling readers

The early years are when the brain develops the most, forming neural connections that pave the way for how a child—and the eventual adult—will express feelings, embark on a task, and learn new skills and concepts. Scientists have even theorized that the anatomical structure of neural connections forms the basis for how children identify letters and recognize words. In other […]

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Sepsis-3 criteria ‘preferable’ in prognostication of critically ill patients

For almost 30 years, diagnostic criteria for sepsis has used the Systemic Inflammatory Response Syndrome (SIRS) criteria in those with suspected infection, with presence of two or more criteria being diagnostic of sepsis. Recently, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) re-evaluated these definitions and introduced the Sequential (Sepsis-related) Organ Failure Assessment (SOFA) score, with an […]

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Exercise may lower mortality in adult survivors of childhood CA

(HealthDay)—For adult survivors of childhood cancer, vigorous exercise in early adulthood is associated with reduced risk of mortality, according to a study published online June 3 in JAMA Oncology. Jessica M. Scott, Ph.D., from the Memorial Sloan Kettering Cancer Center in New York City, and colleagues conducted a multicenter cohort analysis among 15,450 adult cancer survivors diagnosed before age 21 […]

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The Best Baby Carriers on the Market in 2018

What did we ever do before baby carriers? JK. They’ve been around since the dawn of time — and they’ve only gotten fancier. Babywearing is often a parent’s go-to when little ones are fussy (or sleepy or on the move or want to face forward or… anything, really). Also, babywearing makes traveling and shopping way easier because you don’t have to […]

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