Researchers identify a possible cause and treatment for inflammatory bowel disease

Inflammatory bowel disease (IBD) is a category of refractory inflammatory disease, of which ulcerative colitis (UC) and Crohn’s disease (CD) are the main types. Current studies suggest that IBD is a complex autoinflammatory disease determined by genetic and environmental factors, and is the major cause of gastrointestinal cancer. Because of its complex and refractory character, researchers have focused on determining […]

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Hikikomori: New definition helps identify, treat extreme social isolation

Experts in the Japanese phenomena of hikikomori say the condition of extreme social isolation is more widespread than previously acknowledged, and it deserves a clear and consistent definition to improve treatment across the globe. In an article published in the February issue of the journal World Psychiatry, experts cite a lack of broad clinical understanding of the condition. Although hikikomori […]

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Researchers identify neurons responsible for rapid eye movements/REM during sleep

Rapid Eye Movement—not only the name of a successful American rock band, but also and not least a characteristic eye movement in paradoxical sleep, the stage with high dream activity. This sleep phase has a peculiarity: Although the muscle tone of the sleeping person is completely relaxed, the eyes suddenly move back and forth. The name “paradoxical sleep” is well […]

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Scientists identify brain circuit responsible for building memories during sleep

Neuroscientists at the University of Alberta have identified a mechanism that may help build memories during deep sleep. In a study published last month in eNeuro, the researchers focused on the role of the nucleus reuniens, an area of the brain that connects two other brain structures involved in creating memories and may co-ordinate their activity during slow-wave sleep. “Slow […]

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Researchers identify one driver of melanoma spread

Using a small noncoding RNA, microRNA 211, and tools that track the stability and decay of the protein-coding and noncoding RNAs in lab-grown melanoma cells, a team led by a Johns Hopkins Kimmel Cancer Center researcher identified highly unstable RNA molecules in human melanomas, including a novel miR-211 target gene DUSP3. Ranjan J. Perera, Ph.D., associate professor of oncology at […]

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Researchers identify potential target for cardiac fibrosis treatment

A research team led by scientists from the Consortium for Fibrosis Research & Translation (CFReT) at the University of Colorado School of Medicine has identified a potential target for treating heart failure related to fibrosis. Fibrosis is a wound-healing response after tissue injury or stress. Cardiac fibrosis can cause abnormal stiffening of the heart, contributing to the pathogenesis of heart […]

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Researchers identify protein that contributes to racial disparities in prostate cancer

Cancer researchers have long known that prostate cancer tends to be more common, more aggressive and more resistant to existing treatments in African-Americans than in Caucasian-Americans, but they’re only beginning to understand why. A Roswell Park Comprehensive Cancer Center study published today points to cellular factors that appear to be driving these disparities—mitochondrial differences that prevent formation of the cancer-killing […]

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Researchers identify widespread brain alterations in children with callousness

Children with elevated levels of callous traits—such as a lack of remorse and disregard for other people’s feelings—show widespread differences in brain structure compared with children with lower levels of the traits, according to a new study published in Biological Psychiatry. The differences, which included large- and small-scale structural alterations, support the idea of callous traits as a neurodevelopmental condition. […]

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How parents and teachers can identify and help young people self-medicating trauma with drugs and alcohol

Some 80% of young people will experience a traumatic event by the time they become an adult. Rates of exposure to trauma peak during adolescence. The stress from traumatic events can result in a loss of interest in school, friends, hobbies, and life in general. The types of traumatic events include a wide range of terrifying and life-threatening experiences such […]

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