New cellular pathway helps explain how inflammation leads to artery disease

Investigators have identified a new cellular pathway that may help explain how arterial inflammation develops into atherosclerosis—deposits of cholesterol, fats and other substances that create plaque, clog arteries and promote heart attacks and stroke. The findings could lead to improved therapies for atherosclerosis, a leading cause of death worldwide. “We have known for decades that atherosclerosis is a disease of […]

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Scientists discover how brain signals travel to drive language performance

Effective verbal communication depends on one’s ability to retrieve and select the appropriate words to convey an intended meaning. For many, this process is instinctive, but for someone who has suffered a stroke or another type of brain damage, communicating even the most basic message can be arduous. Scientists know that a brain region called the left inferior frontal gyrus […]

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How to Talk to Your Kids About Scary Things

With the Trump administration ripping apart immigrant parents and children at the U.S.-Mexico border, it’s understandable kids (and, let’s be honest, parents) everywhere are feeling scared right now. As with any tragedy, unexplained violence and undelivered justice, current events are likely leaving the kids in your life with big questions that you might find difficult to answer. How can we […]

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Study shows how intensive instruction changes brain circuitry in struggling readers

The early years are when the brain develops the most, forming neural connections that pave the way for how a child—and the eventual adult—will express feelings, embark on a task, and learn new skills and concepts. Scientists have even theorized that the anatomical structure of neural connections forms the basis for how children identify letters and recognize words. In other […]

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Mobile health technology can potentially transform how patients manage heart disease risk

Mobile health technology has the potential to transform the way we prevent and manage heart disease, but there are unanswered questions about how to optimize this technology and maintain engagement with patients, according to a review of randomized clinical trials published in the Canadian Journal of Cardiology. Cardiovascular disease is the leading cause of death worldwide. Recently, mobile health (mHealth) […]

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Researchers discover how colon cancer mutates to escape the immune system

A UCLA-led study has found how colon cancer alters its genes during development in order to avoid detection by the immune system, creating a specific genetic imprint in the process. This ability of cancer to change its genes—a process called immunoediting—had never been described in colon cancer before, and the new understanding could help researchers develop new immunotherapies that target […]

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Scientists show how brain circuit generates anxiety

Neuroscientists at Cold Spring Harbor Laboratory (CSHL) have identified a neural circuit in the amygdala, the brain’s seat of emotion processing, that gives rise to anxiety. Their insight has revealed the critical role of a molecule called dynorphin, which could serve as a target for treatment of anxiety-related disorders including post-traumatic stress disorder (PTSD). Though they are distinct, fear and […]

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Four questions—chronic pain and how it affects the brain

Chronic pain affects an estimated 100 million Americans, and its impact goes beyond physical discomfort. New research, led by University of Arizona psychologist Stephen Cowen, illustrates how chronic pain may impact cognitive abilities, such as decision making, as well. Cowen and UA professor of pharmacology Frank Porreca, along with their collaborators at Eli Lilly, investigated how pain impacts cognitive flexibility, […]

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