Discovery of enhanced bone growth could lead to new treatments for osteoporosis

UCLA and UC San Francisco life scientists have discovered a dramatic pattern of bone growth in female mice—research that could potentially lead to stronger bone density in women and new treatments for osteoporosis in older women. The researchers found that blocking a particular set of signals from a small number of neurons in the brain causes female, but not male, […]

Continue reading »

‘Undruggable’ cancers slowed by targeting growth signals

As many as 50 percent of human cancer cases—across a wide variety of tissues—involve defects in a common cellular growth signaling pathway. These defects have so far defied most attempts to develop targeted therapies, leading some in the field to conclude that they may be “undruggable.” Now researchers at UC San Francisco and Redwood City-based Revolution Medicines, Inc, have identified […]

Continue reading »

Lipid molecules can be used for cancer growth

When the blood supply is low, cancer cells can use lipid molecules as fuel instead of blood glucose. This has been shown in animal tumour models by researchers at Karolinska Institutet, Sweden, in a study published in Cell Metabolism. The mechanism may explain why tumours often develop resistance to cancer drugs that inhibit the formation of blood vessels. Tumour growth […]

Continue reading »

Downward-facing mouse: Stretching reduces tumor growth in mouse model of breast cancer

Many cancer patients seek out gentle, movement-based stretching techniques such as yoga, tai chi and qigong, but does stretching have an effect on cancer? While many animal studies have attempted to quantify the effects of exercise on the disease, results have been mixed. Furthermore, studies in animals involve levels of vigorous exercise that can be difficult for cancer patients. Investigators […]

Continue reading »

New lab study reveals how breast cancer drug can accelerate cancer cell growth

The breast cancer drug lapatinib which is designed to shrink tumours can sometimes cause them to grow in the lab, according to a new study published in eLife. By understanding the molecular basis of this phenomenon, scientists hope that their findings will lead to safer treatment decision-making and drug design in the future. Lapatinib is used in combination with other […]

Continue reading »
1 2