Scientists engineer way to prevent immune response to gene therapy in mice

Health Problems

Stanford University School of Medicine researchers have demonstrated that gene therapy can be effective without causing a dangerous side effect common to all gene therapy: an autoimmune reaction to the normal protein, which the patient’s immune system is encountering for the first time. The researchers showed this in a mouse model that accurately recapitulates Duchenne muscular dystrophy. One in every […]

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Researchers engineer T cells to recognize tumor-specific expression patterns, enhancing tumor response

Health Problems

The advent and advancement of T cell therapy, especially chimeric antigen receptor (CAR)-modified T cells, has demonstrated therapeutic potential in treating previously treatment-resistant tumors. However, few CAR targets are absolutely tumor-specific, resulting in “on-target, off-tumor” toxicities that can be severe. Researchers in the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist […]

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