FDA warns of liver problems for some taking hep C drugs

(HealthDay)—Taking the hepatitis C drugs Mavyret, Zepatier or Vosevi can trigger rare cases of severe liver problems or liver failure in patients who already have moderate-to-severe liver impairment, the U.S. Food and Drug Administration warned Wednesday. The agency has identified 63 cases of worsening liver function, some resulting in liver failure or death, among patients taking the drugs. While the […]

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Researchers 3-D bio-print a model that could lead to improved anticancer drugs and treatments

University of Minnesota researchers have developed a way to study cancer cells which could lead to new and improved treatment. They have developed a new way to study these cells in a 3-D in vitro model (i.e. in a culture dish rather than in a human or animal). In a paper recently published in Advanced Materials, Angela Panoskaltsis-Mortari, Ph.D., Vice […]

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FDA approves drugs for treatment of two rare blood diseases

(HealthDay)—Two drugs have been approved by the U.S. Food and Drug Administration for the treatment of rare blood diseases, the agency announced Friday. Elzonris (tagraxofusp-erzs) infusion was granted the first approval for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and children aged 2 years and older. Researchers investigated the efficacy of Elzonris in two patient cohorts […]

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How parents and teachers can identify and help young people self-medicating trauma with drugs and alcohol

Some 80% of young people will experience a traumatic event by the time they become an adult. Rates of exposure to trauma peak during adolescence. The stress from traumatic events can result in a loss of interest in school, friends, hobbies, and life in general. The types of traumatic events include a wide range of terrifying and life-threatening experiences such […]

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Discovery may lead to safer drugs to save more women in childbirth

Postpartum hemorrhaging is the world’s leading cause of death for women during and after childbirth, and the third-leading cause in the United States alone. Many doctors in developing countries have turned to the drug misoprostol to save more women from deadly bleeding. Misoprostol, although affordable, has dangerous side effects, including uterine cramping, heart attack, toxicity in the brain and spinal […]

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Two genomic tests identify groups of patients most likely to benefit from new drugs

New results from a long-running trial to identify which new drugs or combinations of drugs are most effective in which types of breast cancer, show that two genomic tests are bringing the era of truly personalised medicine ever nearer. Professor Laura van ‘t Veer, leader of the Breast Oncology Program at the University of California San Francisco, USA, told the […]

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Switching to certain antidiabetic drugs linked to increased risk of major complications

For people with type 2 diabetes, switching to sulfonylurea drugs to control blood sugar levels is associated with an increased risk of complications compared with staying on the drug metformin, finds a study in The BMJ today. As such, the researchers say that continuing metformin when introducing sulfonylureas is safer than switching. Metformin is a “first-line” therapy (the first drug […]

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Computer algorithm maps cancer resistance to drugs, therapy

New methods of studying the evolution of treatment resistance in head and neck cancer are being developed by researchers at the Johns Hopkins Kimmel Cancer Center. The scientists wanted to examine how cancers acquire resistance to treatment over time and whether those changes could be modeled computationally to determine patient-specific timelines of resistance. The research was published by Genome Medicine […]

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