Restoring protein homeostasis improves memory deficits in Down syndrome model

Down syndrome is the most common genetic cause of intellectual disability, and currently there is no effective treatment. Memory deficits are a hallmark of this condition and a study published today in the journal Science reports that the defects in a conserved stress pathway dubbed the ‘integrated stress response,’ or ISR, could explain the cognitive deficits in a mouse model […]

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New approach to shutting down breast cancer recurrence shows promise in mice

A new approach to treat advanced breast cancer shuts down the growth of cells that become resistant to standard hormone therapy, according to Duke Cancer Institute animal studies. The research, which is likely to be tested in clinical trials within the year, identified and targeted vulnerabilities that appear in nearly all estrogen-positive breast cancers that develop resistance to current treatments. […]

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Anesthesia sends neurons down the wrong path in unborn rat babies

While there has long been discussion whether exposure to anesthesia affects brain development, new Rush University Medical Center research published in the journal Cerebral Cortex describes how prenatal anesthesia in rats seems to disrupt the “precisely choreographed” and timed migration of neurons to the area of the developing brain where thinking, memory and language occur. The finding further fuels the […]

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Breaking down AGEs: Insight into how lifestyle drives ER-positive breast cancer

Poor diet and lack of exercise are associated with cancer development, but the underlying biology is not well understood. Advanced glycation end products (AGEs) could offer a biological link to help us understand how certain lifestyle behaviors increase cancer risk or lessen the likelihood that an anti-cancer therapy will be effective. AGE accumulation is the natural and unavoidable result of […]

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Understanding Down syndrome opens door to Alzheimer’s prevention trials

Clinical trials for preventing Alzheimer’s disease in people with Down syndrome may soon be possible thanks to new research from King’s College London. The researchers found changes in memory and attention are the earliest signs of Alzheimer’s in Down syndrome, and these changes start in the early 40s. People with Down syndrome have an extremely high risk of developing Alzheimer’s […]

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