Engineered DNA vaccine protects against emerging Mayaro virus

Infections by the mosquito-borne Mayaro virus (MAYV) have largely been restricted to people who ventured into the heavily forested areas of Trinidad and Tobago and neighboring regions of South America. However, recent laboratory studies showing additional mosquito vectors can transmit MAYV as well as a reported case of MAYV infection in Haiti in 2015, reveal the potential for the virus […]

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Larotrectinib: Targeting DNA in cancer therapy

While other toddlers her age were fighting naptime, two-year-old Michelle was battling an aggressive, life-threatening cancer. Doctors at Children’s Hospital Los Angeles saved her life in an epic battle, wielding what is being hailed as a “magic bullet” in the fight against certain cancers. CHLA’s Leo Mascarenhas, MD, MS, saw promise in larotrectinib when he helped design the clinical trial […]

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Healthy blood stem cells have as many DNA mutations as leukemic cells

Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ. Rather, the location of DNA mutations is relevant. Using the mutation patterns in hematopoietic stem and progenitor cells (HSPCs), the team was able to trace the developmental lineage tree of the cells. Van Boxtel, […]

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Cell-free DNA profiling informative way to monitor urinary tract infections

Using shotgun DNA sequencing, Cornell University researchers have demonstrated a new method for monitoring urinary tract infections (UTIs) that surpasses traditional methods in providing valuable information about the dynamics of the infection as well as the patient’s biological response. The technique is detailed in the paper “Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract,” […]

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Scientists help identify genetic markers for prostate cancer in global DNA download

An international team of researchers including USC scientists has found scores of new genetic markers in DNA code that increase prostate cancer risk—powerful knowledge likely to prove useful to detect and prevent the disease. Focusing on DNA of more than 140,000 men worldwide, researchers were able to identify 63 new genetic markers associated with prostate cancer risk. That greatly increases […]

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