Researchers identify a possible cause and treatment for inflammatory bowel disease

Inflammatory bowel disease (IBD) is a category of refractory inflammatory disease, of which ulcerative colitis (UC) and Crohn’s disease (CD) are the main types. Current studies suggest that IBD is a complex autoinflammatory disease determined by genetic and environmental factors, and is the major cause of gastrointestinal cancer. Because of its complex and refractory character, researchers have focused on determining […]

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The right mouse model is crucial for Huntington’s disease drug development

Huntington’s disease (HD) is an incurable and fatal hereditary disease. Developing disease-modifying drugs to treat patients with HD depends on studying them in animal models. Scientists evaluated the mouse models used for developing new treatments for mood disorders in HD and recommended which of these models are most relevant to their studies. Their findings are published in the Journal of […]

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New study provides insight into chronic kidney disease

Researchers have further analyzed a known signaling pathway they believe brings them one step closer to understanding the complex physiology of patients with chronic kidney disease (CKD), which might provide a path to new treatment options. CKD is a complex and unique condition that involves impaired removal of many different toxins from the blood. These toxins, which often are referred […]

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Bag of words test for Alzheimer’s disease

A positive diagnosis of Alzheimer’s disease (AD) can only be made definitively postmortem. However, there are many symptoms that become apparent as the disease progresses and specialists can usually be quite certain of a diagnosis. However, as with many diseases, the later the diagnosis, the less successful medical interventions will generally be. New research published in the International Journal of […]

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Drug treats inflammation associated with genetic heart disease that can be deadly in young athletes

When young athletes experiences sudden cardiac death as they run down the playing field, it’s usually due to arrhythmogenic cardiomyopathy (ACM), an inherited heart disease. Now, Johns Hopkins researchers have shed new light on the role of the immune system in the progression of ACM and, in the process, discovered a new drug that might help prevent ACM disease symptoms […]

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New test diagnoses Lyme disease within 15 minutes

Some 300,000 people in the U.S. are diagnosed with Lyme disease every year. Caused by Borrelia burgdorferi and transmitted by the bite of infected Ixodes ticks, the disease if left untreated can cause serious neurologic, cardiac, and/or rheumatologic complications. Current testing for Lyme disease, called the standard 2-tiered approach or the STT, involves running two complex assays (ELISA and western […]

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Study reveals how fungal biofilm structure impacts lung disease

Findings from an innovative new study led by researchers at Dartmouth’s Geisel School of Medicine and published this week in Nature Microbiology reveal that the way in which human fungal pathogens form colonies can significantly impact their ability to cause disease. Highly diverse and adaptable, these colonies, known as biofilms, allow invasive fungal pathogens such as Aspergillus fumigatus to grow […]

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Certain genetic variants predispose patients with diabetes to kidney disease

In an unprecedented scale, researchers have begun to unravel the genetics that may predispose some individuals to develop kidney disease once they have diabetes, independent of the degree of blood sugar control. The findings appear in an upcoming issue of JASN. Many individuals with type 1 diabetes develop kidney disease despite adequate blood sugar control, while others maintain normal kidney […]

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An innovative new diagnostic for Lyme disease

When researchers examined the mitochondrial DNA of Ötzi, a man entombed in ice high in the Tyrolean Alps some 5,300 years ago, they made a startling discovery. Secreted within the tangles of the ice man’s genetic code was evidence he’d been infected with a bacterial pathogen, Borrelia burgdorferi. Ötzi is the first known case of Lyme disease. Today, Lyme disease […]

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