Bag of words test for Alzheimer’s disease

A positive diagnosis of Alzheimer’s disease (AD) can only be made definitively postmortem. However, there are many symptoms that become apparent as the disease progresses and specialists can usually be quite certain of a diagnosis. However, as with many diseases, the later the diagnosis, the less successful medical interventions will generally be. New research published in the International Journal of […]

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Drug treats inflammation associated with genetic heart disease that can be deadly in young athletes

When young athletes experiences sudden cardiac death as they run down the playing field, it’s usually due to arrhythmogenic cardiomyopathy (ACM), an inherited heart disease. Now, Johns Hopkins researchers have shed new light on the role of the immune system in the progression of ACM and, in the process, discovered a new drug that might help prevent ACM disease symptoms […]

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New test diagnoses Lyme disease within 15 minutes

Some 300,000 people in the U.S. are diagnosed with Lyme disease every year. Caused by Borrelia burgdorferi and transmitted by the bite of infected Ixodes ticks, the disease if left untreated can cause serious neurologic, cardiac, and/or rheumatologic complications. Current testing for Lyme disease, called the standard 2-tiered approach or the STT, involves running two complex assays (ELISA and western […]

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Study reveals how fungal biofilm structure impacts lung disease

Findings from an innovative new study led by researchers at Dartmouth’s Geisel School of Medicine and published this week in Nature Microbiology reveal that the way in which human fungal pathogens form colonies can significantly impact their ability to cause disease. Highly diverse and adaptable, these colonies, known as biofilms, allow invasive fungal pathogens such as Aspergillus fumigatus to grow […]

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Certain genetic variants predispose patients with diabetes to kidney disease

In an unprecedented scale, researchers have begun to unravel the genetics that may predispose some individuals to develop kidney disease once they have diabetes, independent of the degree of blood sugar control. The findings appear in an upcoming issue of JASN. Many individuals with type 1 diabetes develop kidney disease despite adequate blood sugar control, while others maintain normal kidney […]

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An innovative new diagnostic for Lyme disease

When researchers examined the mitochondrial DNA of Ötzi, a man entombed in ice high in the Tyrolean Alps some 5,300 years ago, they made a startling discovery. Secreted within the tangles of the ice man’s genetic code was evidence he’d been infected with a bacterial pathogen, Borrelia burgdorferi. Ötzi is the first known case of Lyme disease. Today, Lyme disease […]

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Deep brain stimulation eases Parkinson’s disease symptoms by boosting dopamine

In a new study of seven people with Parkinson’s disease, Johns Hopkins Medicine researchers report evidence that deep brain stimulation using electrical impulses jumpstarts the nerve cells that produce the chemical messenger dopamine to reduce tremors and muscle rigidity that are the hallmark of Parkinson’s disease, and increases feelings of well-being. “While deep brain stimulation has been used for treating […]

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Smart brain stimulators: Next-gen parkinson’s disease therapy

Researchers at the University of Houston have found neuro biomarkers for Parkinson’s disease that can help create the next generation of “smart” deep brain stimulators, able to respond to specific needs of Parkinson’s disease patients. Those with the disease often undergo the high-frequency brain stimulation, a well-established therapy for the progressive nervous system disorder that affects movement, but the therapy […]

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Researchers tie metabolic enzyme to obesity and fatty liver disease

Researchers from Clemson University’s Environmental Toxicology Program have published research connecting an enzyme associated with detoxification to obesity and fatty liver disease, especially in males. William Baldwin, professor and graduate program coordinator in the College of Science’s department of biological sciences, and members of his laboratory used a novel mouse model developed in their laboratory to study the role of […]

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