Pediatric onset multiple sclerosis study examines baffling, often-overlooked disease

Seemingly overnight, healthy children develop mysterious, potentially disabling symptoms. When children finally receive a diagnosis, often after weeks of tests and office and hospital visits, the parents may be shocked to learn that they have multiple sclerosis—a potentially disabling autoimmune disease once believed to affect only adults. “For many years, the tagline for MS was that it was the ‘leading […]

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Dry eye disease and diabetes: New study reveals scale of issue and need for screening

Credit: Shutterstock Diabetes is a debilitating health condition which is expected to reach epidemic proportions in the next 20 years. According to the World Health Organisation, 108m people around the world had diabetes in 1980; by 2014 that figure was 422m. Three years later in 2017, 425m people worldwide were living with the disease and this figure is expected to […]

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Is kidney failure a man’s disease?

A new analysis of the ERA-EDTA Registry reveals a striking gender difference in the incidence and prevalence of end-stage renal disease. Two thirds of all dialysis patients in Europe are male. It seems beyond hormonal effects that hypertension, diabetes and glomerulonephritis/sclerosis are the main driver of the gender gap. However, it is possible to prevent and treat hypertension and diabetes […]

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Gene-edited disease monkeys cloned in China

The first cohort of five gene-edited monkey clones made from fibroblasts of a monkey with disease phenotypes were born recently at the Institute of Neuroscience (ION) of the Chinese Academy of Sciences (CAS) in Shanghai. The expression of BMAL1, a core circadian regulatory transcription factor, was knocked out in the donor monkey using CRISPR/Cas9-mediated gene editing at the embryo stage, […]

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Liver transplants double for alcohol-related liver disease

The proportion of U.S. liver transplants for alcohol-associated liver disease (ALD) has doubled in the last 15 years, in part due to broader acceptance of waiving the mandated period of sobriety before transplants for this population, according to a study by researchers at UC San Francisco. However, the study showed ongoing regional geographic variations in liver transplant rates for ALD […]

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New light-based technology reveals how cells communicate in human disease

Scientists at the University of York have developed a new technique that uses light to understand how cells communicate in human disease. All cells in the human body communicate with each other by releasing signalling molecules; this helps to ensure that tissues function normally, that the immune system is able to respond to infection, and that cell division and survival […]

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