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A technique using live human cancer tissue to develop the next generation of cancer drugs is being developed in South Australia. The researchers from the University of Adelaide are using the technique to fill the void between animal testing and clinical trials in a bid to cut the cost and time of drug development and reduce the failure rate in […]
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University of Melbourne researchers have identified a protein involved in rheumatoid arthritis-induced inflammation that could lead to new drug treatments for people who do not respond to current therapies. Arthritis is Australia’s most common chronic disease and affects more than 3.5 million people. Rheumatoid arthritis (RA) affects about one per cent of the population and is one of the most […]
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At birth, the brain is the most underdeveloped organ in our body. It takes up until our mid-20s for our brains to fully mature. Any serious and prolonged adversity, such as a sudden, unexpected and lasting separation from a caretaker, changes the structure of the developing brain. It damages a child’s ability to process emotion and leaves scars that are […]
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A new Tel Aviv University study identifies a previously unknown mechanism involved in the development of Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS). The research focuses on a specific microRNA whose levels were found to decrease as a result of ALS-causing muscular mutations. The study highlights, for the first time, the importance of toxic muscle-secreting molecules in the pathology […]
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Scientists have shown for the first time that the blueprint for the four chambers of the human heart exists in the humble zebrafish, a study in eLife reports. The discovery provides key insights into processes that go wrong in congenital heart defects and means that researchers now have a simple model for further research that more closely reflects what happens […]
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Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow that comprises 1 percent of all new cancer cases and almost 2 percent of cancer deaths in the U.S. The five-year survival rate for the disease is less than 20 percent. Researchers at the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore […]
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A team of researchers from several institutions in China has found a mechanism that appears to drive the development of a type of liver cancer not caused by alcohol consumption. In their paper published in the journal Science Translational Medicine, the group describes their study of liver cancer in mouse models and what they found. Ngee Kiat Chua, Hudson Coates […]
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The disease mechanism for adult-onset progressive degenerative diseases begins much earlier than previously thought, according to a Northwestern Medicine study published in the Journal of Clinical Investigation. Using a mouse model of spinocerebellar ataxia type 1 (SCA1) genetically engineered to precisely mirror the human disease, a team of investigators showed that there is an altered neural circuitry in the cerebellum […]
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