Researchers unveil experimental compound to block therapeutic target in blood cancer

Researchers at the UNC Lineberger Comprehensive Cancer Center have discovered a hyperactive cell signal that contributes to tumor growth in an aggressive blood cancer. They also developed an experimental therapeutic to block the signal and slow tumor growth. The researchers reported in the journal Proceedings of the National Academy of Sciences they identified a novel therapeutic target for primary effusion […]

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Biochemical compound responsible for blood pressure drop in sepsis is discovered

A study conducted by an international group of researchers has overturned the understanding of life-threatening inflammatory diseases such as sepsis, pointing to a biochemical agent that may be involved in the rapid decline in blood pressure that occurs in the advanced stage of sepsis and usually causes the patient’s death. This discovery could pave the way for novel therapeutic approaches. […]

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New compound advances into Phase 1 trial for pancreatic cancer

A compound discovered at Sanford Burnham Prebys Medical Discovery Institute (SBP) has advanced into a Phase 1 trial for metastatic pancreatic cancer. Called CEND-1 (scientifically known as iRGD), the compound was exclusively licensed in 2015 to a private company, DrugCendR Inc. The drug candidate was discovered in the laboratory of Erkki Ruoslahti, M.D., Ph.D., distinguished professor at SBP and founder, […]

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Compound identified that protects against neurodegeneration

Researchers from the University of Liverpool have identified a new compound that protects against neurodegeneration in nematode worms. The discovery may enable novel treatments for human neurodegenerative diseases to be developed in the future. With the predicted growth of the global ageing population, cases of age-associated neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS) are […]

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Compound improves stroke outcome by reducing lingering inflammation

An experimental compound appears to improve stroke outcome by reducing the destructive inflammation that can continue months after a stroke, scientists report. Rats consuming compound 21 following a clot-based stroke – the most common type in humans – don’t have a smaller stroke size but do have better memory and movement in its aftermath, says Dr. Adviye Ergul, vascular physiologist […]

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