New method classifies brain cells based on electrical signals

For decades, neuroscientists have relied on a technique for reading out electrical “spikes” of brain activity in live, behaving subjects that tells them very little about the types of cells they are monitoring. In a new study, researchers at the University of Tuebingen and MIT’s Picower Institute for Learning and Memory demonstrate a way to increase their insight by distinguishing […]

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Tiny blood cells could protect against cerebral palsy

Platelets—tiny cells critical for blood clotting—could be the key to protecting against brain damage occurring during pregnancy or around the time of birth. Information gained from the pre-clinical study led by Dr. Alison Farley and Dr. Samir Taoudi from the Walter and Eliza Hall Institute could enable doctors to intervene at the right time to prevent brain bleeds—a significant risk […]

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Uncovering secrets of bone marrow cells and how they differentiate

Bone marrow contains biological factories, which pump out billions of new blood cells daily. The non-blood cells that maintain this production also have the potential to produce bone, fat and cartilage. This output all starts from stem cells that have the ability to differentiate into various types of cells. Knowledge of the genes that control this differentiation and the paths […]

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To assess a cell’s health, follow the glucose

A new spectroscopic technique reveals that glucose use in live cells provides valuable information about the functional status of cells, tissues, and organs. Shifts in a cell’s use of glucose can signal changes in health and progress of disease. How a cell uses glucose has long been a window on overall health. However, existing glucose-imaging tools have only been able […]

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How DNA outside cells can be targeted to prevent the spread of cancer

Cell-free DNA (cfDNA) is DNA found in trace amounts in blood, which has escaped degradation by enzymes. Scientists from Tokyo University of Science, led by Prof Ryushin Mizuta, have now discovered exactly how cfDNA is generated. They also talk about the applications of DNase1L3—the enzyme mainly responsible for generating cfDNA—as a novel molecule to prevent the spread of tumors. Prof […]

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New study reveals an unexpected survival mechanism of a subset of cancer cells

Embedded at the ends of chromosomes are structures called telomeres, which in normal cells become shorter as cells divide. Progressive shortening triggers cell proliferation arrest or death. Cancer cells adopt different strategies to overcome this control mechanism that keeps track of the number of times that a cell has divided. One of these strategies is the alternative lengthening of telomeres […]

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