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Enzyme identified as possible novel drug target for sickle cell disease, Thalassemia

22.07.2018 Health Problems

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease (SCD). Experiments in cultured human cells reveal that blocking the protein reduces the characteristic sickling that distorts the shape of red blood cells and gives the disease its name. “We […]

Cell type and environment influence protein turnover in the brain

20.06.2018 Health Problems

Scientists have revealed that protein molecules in the brain are broken down and replaced at different rates, depending on where in the brain they are. The study, published in eLife, provides essential insights into how the components of different cells in the brain are altered. These kinds of alterations may be important in our abilities to learn and form memories, […]

Targeting the engine room of the cancer cell

19.06.2018 Health Problems

Researchers at Columbia University Irving Medical Center (CUIMC) have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug combinations that are most likely to kill them. The study, published today on Nature Genetics, by Dr. Andrea Califano of Columbia University Irving Medical Center and Dr. Irvin Modlin of […]

The Question Every Parent Dreads: Can I Take My Cell Phone to School?

17.06.2018 Kids Health

It’s a dilemma every parent has to face at some point: Should I let my kid take a cell phone to school? A 2010 Pew Research Center study found that 65 percent of cell-owning teens bring their phones to school whether the school permits them or not. Most schools allow students to have cell phones with certain rules in place, […]

Checkpoint inhibitor shrinks advanced squamous cell skin cancer

05.06.2018 Health Problems

Clinical trials show that an immune checkpoint inhibitor shrinks the tumors of nearly half of patients with an incurable, advanced form of a common skin cancer, an international team led by a researcher at The University of Texas MD Anderson Cancer Center reports in the New England Journal of Medicine. “These results mark a potential paradigm shift in the treatment […]

Chronic lymphocytic leukemia patient goes into remission thanks to single CAR T cell

30.05.2018 Health Problems

The doctors who have spent years studying the case call it “a series of fortunate events.” What began as a remarkable response to chimeric antigen receptor (CAR) T cell therapy is now providing evidence about the human genome and immune response that could help turn gene therapy non-responders into responders. Researchers at the University of Pennsylvania’s Abramson Cancer Center say […]

Researcher: Big data, networks identify cell signaling pathways in lung cancer

23.05.2018 Health Problems

A team of scientists led by University of Montana cell biologist Mark Grimes has identified networks inside lung cancer cells that will help understand this cancer and fight it with drug treatments. The paper, published as the cover article of the May 22 issue of Science Signaling, sheds light on how a new class of drugs called HSP90 inhibitors—which are […]

Colon cancer cells use mysterious RNA strands to avoid cell death

17.05.2018 Health Problems

Researchers from Case Western Reserve University School of Medicine have discovered how unusually long strands of RNA help colon cancer cells avoid death, allowing unregulated growth. Unlike other RNAs, the intriguing strands do not appear to encode proteins and are termed “long non-coding RNAs” or “lincRNAs.”A new study showed some lincRNAs could be targeted by drug developers to halt colon […]

Cell phones at summer camp: Research explores the effects

08.05.2018 Kids Health

Summer camp often conjures up images of wooded retreats with lakes and cabins, camping under the stars and making new friendships over campfires and outdoor adventures. But today’s camp counselors have a new scene to contend with: Young campers on their phones. New research from University of Michigan C.S. Mott Children’s Hospital delves into how digital media might affect the […]

New lab study reveals how breast cancer drug can accelerate cancer cell growth

01.05.2018 Health Problems

The breast cancer drug lapatinib which is designed to shrink tumours can sometimes cause them to grow in the lab, according to a new study published in eLife. By understanding the molecular basis of this phenomenon, scientists hope that their findings will lead to safer treatment decision-making and drug design in the future. Lapatinib is used in combination with other […]

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