Enzyme identified as possible novel drug target for sickle cell disease, Thalassemia

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease (SCD). Experiments in cultured human cells reveal that blocking the protein reduces the characteristic sickling that distorts the shape of red blood cells and gives the disease its name. “We […]

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Targeting the engine room of the cancer cell

Researchers at Columbia University Irving Medical Center (CUIMC) have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug combinations that are most likely to kill them. The study, published today on Nature Genetics, by Dr. Andrea Califano of Columbia University Irving Medical Center and Dr. Irvin Modlin of […]

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Chronic lymphocytic leukemia patient goes into remission thanks to single CAR T cell

The doctors who have spent years studying the case call it “a series of fortunate events.” What began as a remarkable response to chimeric antigen receptor (CAR) T cell therapy is now providing evidence about the human genome and immune response that could help turn gene therapy non-responders into responders. Researchers at the University of Pennsylvania’s Abramson Cancer Center say […]

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Colon cancer cells use mysterious RNA strands to avoid cell death

Researchers from Case Western Reserve University School of Medicine have discovered how unusually long strands of RNA help colon cancer cells avoid death, allowing unregulated growth. Unlike other RNAs, the intriguing strands do not appear to encode proteins and are termed “long non-coding RNAs” or “lincRNAs.”A new study showed some lincRNAs could be targeted by drug developers to halt colon […]

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Cell phones at summer camp: Research explores the effects

Summer camp often conjures up images of wooded retreats with lakes and cabins, camping under the stars and making new friendships over campfires and outdoor adventures. But today’s camp counselors have a new scene to contend with: Young campers on their phones. New research from University of Michigan C.S. Mott Children’s Hospital delves into how digital media might affect the […]

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New lab study reveals how breast cancer drug can accelerate cancer cell growth

The breast cancer drug lapatinib which is designed to shrink tumours can sometimes cause them to grow in the lab, according to a new study published in eLife. By understanding the molecular basis of this phenomenon, scientists hope that their findings will lead to safer treatment decision-making and drug design in the future. Lapatinib is used in combination with other […]

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