Interaction between two immune cell types could be key to better dengue vaccines, study shows

Researchers at Duke-NUS Medical School have demonstrated for the first time a physical interaction between two types of immune cells that plays an important role in the early fight against dengue virus infection. Dengue virus is widespread in the tropics and is transmitted by mosquitos. Dengue virus infection incidence has grown dramatically in recent years, with estimates suggesting 390 million […]

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In vitro cell culture findings could lead to novel interventions for schizophrenia

A study recently published in Translational Psychiatry, a Nature journal, has shown how using cultured cells from patients with psychotic disorders, such as schizophrenia, to investigate abnormalities in nerve connections in the brain could lead to new treatments. Strong correlations were observed between the findings in the cells in culture—grown outside the body in a controlled environment—and findings from brain […]

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As stem cell and gene technologies advance, La Jolla conference mushrooms

In 2006, a few hundred mostly local researchers gathered in La Jolla to discuss the emerging but still science-fictiony field of stem cells. Since then, stem cells, enhanced by gene therapy, have progressed to yield breakthrough treatments, most spectacularly in cancer. Likewise, the conference known as the Cell & Gene Meeting on the Mesa has mushroomed into an international event. […]

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Researchers find adult stem cell characteristics in aggressive cancers from different tissues

UCLA researchers have discovered genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues—which line all of the organs and cavities inside the body—and the cells that drive aggressive epithelial cancers. Their findings could bring about a better understanding of how aggressive, treatment-resistant cancers develop and progress, and could eventually lead to new drugs for a […]

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New stem cell model can be used to test treatments for a rare nervous system disorder

A City of Hope researcher has developed a stem cell model to assess possible treatments for a rare nervous system disorder that is in the same disease group as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). The finding takes Yanhong Shi, Ph.D., senior author of the study, and her colleagues one step closer to finding a way to […]

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Liver cancer cell ‘switch’ found that could improve future therapies

Imperial researchers have found a new cell mechanism that could be used to target tumours in the future. The newly discovered ‘switch’ controls the activity of two proteins – ‘deleted in liver cancer-1’ (DLC1), a tumour suppressor, and talin. Both proteins control whether or not cancer cells spread to other parts of the body, but the exact mechanisms have remained […]

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Enzyme identified as possible novel drug target for sickle cell disease, Thalassemia

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease (SCD). Experiments in cultured human cells reveal that blocking the protein reduces the characteristic sickling that distorts the shape of red blood cells and gives the disease its name. “We […]

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