New way of measuring white blood cell function offers better insights to help patients with sepsis

Caring for a patient with sepsis requires walking a treatment tightrope. Clinicians must identify the pathogen that is causing a patient’s infection, carefully monitor the patient’s response to antibiotics and supportive measures and race against the clock to prevent potential organ failure and death. Most of the time, physicians can control the infection itself. What ultimately leads to multi-organ system […]

Continue reading »

Novel regulator of mitochondrial cell death reveals a promising target for cancer therapy

Researchers at The Wistar Institute have described the role of mitochondrial fission factor (MFF) in controlling survival of cancer cells, suggesting the protein could represent a promising therapeutic target. They also found that expression of MFF is regulated by Myc, a ubiquitous mediator of cell proliferation that contributes to development of many cancer types. These results were published online in […]

Continue reading »

100-year-old scientific mystery solved: Researchers discover role of nuclear glycogen in non-small cell lung cancers

Researchers at the University of Kentucky Markey Cancer Center have made a breakthrough discovery that solves a mystery long forgotten by science and have identified a potentially novel avenue in pre-clinical models to treat non-small cell lung cancers. Published in Cell Metabolism, the research centers on the function of glycogen accumulation in the nucleus of a cell. Glycogen is known […]

Continue reading »

Targeting cell division in pancreatic cancer

Pancreatic cancer is one of the deadliest cancers, with patients surviving on average less than a year once the disease has spread. There is an urgent need to evaluate more therapeutic targets. The chemotherapeutic agent abemaciclib is effective in treating breast cancer, but there is limited preclinical evaluation of this targeted therapy in treating pancreatic cancer. New research from Sidney […]

Continue reading »

Injectable ‘bone spackling’: A cell therapy approach to heal complex fractures

Large, complex bone wounds are hard for doctors and patients alike to contend with. They often require grafts and multiple surgeries. Jan Stegemann, a University of Michigan professor of biomedical engineering, is reprogramming adult cells from bone marrow so that they can be injected directly into a wound and grow into bone. The marrow-derived cells are known as progenitor cells, […]

Continue reading »

Mechanical forces control cell fate during brain formation

A new study coordinated by the Research Group in Developmental Biology at UPF shows that during the embryonic development of the brain, the cells that are between adjacent segments detect the mechanical forces generated during morphogenesis to regulate the balance between progenitor stem cells and differentiated neurons. The study has been published in the journal Development. In vertebrates, the central […]

Continue reading »

Researchers discover new cause of cell aging

New research from the USC Viterbi School of Engineering could be key to our understanding of how the aging process works. The findings potentially pave the way for better cancer treatments and revolutionary new drugs that could vastly improve human health in the twilight years. The work, from Assistant Professor of Chemical Engineering and Materials Science Nick Graham and his […]

Continue reading »
1 2 3 4