Seven-country study reveals viruses as new leading cause of global childhood pneumonia

Respiratory syncytial virus (RSV) and other viruses now appear to be the main causes of severe childhood pneumonia in low- and middle-income countries, highlighting the need for vaccines against these pathogens, according to a study from a consortium of scientists from around the world, led by a team at the Johns Hopkins Bloomberg School of Public Health. Pneumonia is the […]

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Viral strains that cause ‘stomach flu’ don’t all look alike

Stomach bugs come in different sizes. Norovirus, best known for sweeping through daycares and cruise ships, can form small, medium, and large structures depending on the viral strain. The discovery, reported June 10, 2019, in the journal Proceedings of the National Academy of Sciences, overturns nearly two decades of conventional wisdom about norovirus. Until now, the only structural data about […]

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Researchers find the cause of and cure for brain injury associated with gut condition

Using a mouse model of necrotizing enterocolitis (NEC)—a potentially fatal condition that causes a premature infant’s gut to suddenly die—researchers at Johns Hopkins say they have uncovered the molecular causes of the condition and its associated brain injury. The discovery enabled the team to combine efforts with colleagues studying brain inflammation and to identify potential drugs that reverse the brain […]

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Why does diabetes cause heart failure?

Men with diabetes are 2.4 times more likely than non-diabetics to suffer heart failure and women are five times more likely. A new Loyola University Chicago Stritch School of Medicine study reveals how, on a cellular level, diabetes can cause heart failure. The findings could lead to medications to treat and perhaps prevent heart failure in diabetes patients, researchers said. […]

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The cause of prostate cancer progression to the incurable stage has likely been uncovered

Researchers at the University of Oulu in Finland have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism (SNP) rs11672691 influences prostate cancer aggressiveness. Their findings also suggest ways to improve risk stratification and clinical treatment for advanced prostate cancer. The study is published in the journal Cell. Three billion base pairs […]

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Study reveals long-term effectiveness of therapy for common cause of kidney failure

New research provides support for the long-term efficacy of a drug used to treat in patients with autosomal dominant polycystic kidney disease (ADPKD), a common cause of kidney failure. The findings appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The hormone vasopressin promotes the progression of ADPKD, the fourth leading cause of […]

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Irrigation water likely cause of romaine lettuce E. coli outbreak

(HealthDay)—Tainted irrigation water is likely to blame for a 36-state Escherichia coli outbreak linked to romaine lettuce that sickened 200 people and caused five deaths, U.S. health officials say. The illnesses were previously connected with romaine lettuce grown in Yuma, Ariz., which supplies most of the romaine sold in the United States during the winter, the Associated Press reported. Further […]

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