Survivors of childhood cancers at risk for shortened life span

(HealthDay)—Survivors of childhood cancer remain at risk for shorter life spans, especially when they receive radiotherapy, according to a study published online Jan. 2 in JAMA Oncology. Jennifer M. Yeh, Ph.D., from the Harvard Medical School in Boston, and colleagues conducted a microsimulation model of competing mortality risks using data from the Childhood Cancer Survivor Study on five-year survivors of […]

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Ancient viruses could help kill cancers

DNA “echoes” of viruses that infected our ancestors millions of years ago could help the immune system to identify and kill cancer cells, according to new research from Crick scientists. The new study, published in Genome Research, looked at “endogenous retroviruses,” fragments of DNA in the human genome that were left behind by viruses that infected our ancestors. Over millions […]

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100-year-old scientific mystery solved: Researchers discover role of nuclear glycogen in non-small cell lung cancers

Researchers at the University of Kentucky Markey Cancer Center have made a breakthrough discovery that solves a mystery long forgotten by science and have identified a potentially novel avenue in pre-clinical models to treat non-small cell lung cancers. Published in Cell Metabolism, the research centers on the function of glycogen accumulation in the nucleus of a cell. Glycogen is known […]

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Diet high in leucine may fuel breast cancer’s drug resistance

About one in eight women in the United States will develop breast cancer in their lifetime. The vast majority of these cancers rely on the hormone estrogen to grow. Estrogen-receptor positive (ER+) breast cancer tumors are frequently treated with the drug tamoxifen, which blocks the hormone’s effect on the tumor. However, many tumors eventually become resistant to tamoxifen, allowing cancer […]

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Obesity and alcohol responsible for nearly 30,000 cases of breast cancers in the next decade

Maintaining a healthy weight and not consuming alcohol regularly could help prevent thousands of breast cancer cases, a new big data study by UNSW Sydney researchers has found. The findings could help inform future cancer control strategies. The large collaborative study led by UNSW’s Centre for Big Data Research in Health was published in the International Journal of Cancer. It […]

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Breast cancer’s deadliness is influenced by genes

An international team of scientists have confirmed that both rare and common mutations of our genes are linked to the development of breast cancer, including tumour characteristics and corresponding deadliness. Interestingly, they discovered that the rare mutations were linked to more aggressive tumours, while the common mutations were associated with less aggressive tumour characteristics. The study was led by Dr. […]

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Fat fuels aggressive brain cancers

Fat is powering tumour growth in brain cancer, finds a new study by Cardiff University and the University of Florida. Investigating the different types of cells in glioblastoma, the research team have gained a valuable insight into what fuels slow and fast dividing cancer cells, unveiling the potential to target aggressive brain cancer more effectively. Dr. Florian Siebzehnrubl, European Cancer […]

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Why some cancers affect only young women

Among several forms of pancreatic cancer, one of them specifically affects women, often young. How is this possible, even though the pancreas is an organ with little exposure to sex hormones? This pancreatic cancer, known as “mucinous cyst”, has strange similarities with another mucinous cancer, affecting the ovaries. By conducting large-scale analyses of genomic data, researchers at the University of […]

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Five cancers women must be vigilant about

We asked some of Roswell Park’s doctors who specialize in cancers that affect women to share some tips for preventing or treating cancer. Here’s what they offered. Breast Cancer Breast cancer is the most frequently diagnosed cancer in women. Most women who are diagnosed with breast cancer do not actually have a family history of breast cancer. “Since 1990, the […]

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