Exploration of umbelliferone based derivatives as potent MAO inhibitors

Monoamine oxidase (MAO) inhibitors are potential drug candidates for treating neurological disorders such as anxiety, Alzheimer’s disease and Parkinson’s disease. This review presents information about MAO inhibitory effects of the umbelliferone based derivatives. The potential antioxidant effects of the derivatives were evaluated by DPPH and H2O2 scavenging methods. The derivatives were screened for hMAO-A and hMAO-B inhibition through a series […]

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Concussion-related biomarkers vary based on sex, race

(HealthDay)—Concussion-related serum biomarkers vary by sex and race, which may complicate their interpretation, according to three studies published online Nov. 7 in Neurology. Breton M. Asken, from the University of Florida in Gainesville, and colleagues conducted an observational cohort study and measured serum concentrations of biomarkers in 415 nonconcussed collegiate athletes without recent exposure to head impacts to describe the […]

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