Exploration of umbelliferone based derivatives as potent MAO inhibitors

Monoamine oxidase (MAO) inhibitors are potential drug candidates for treating neurological disorders such as anxiety, Alzheimer’s disease and Parkinson’s disease. This review presents information about MAO inhibitory effects of the umbelliferone based derivatives. The potential antioxidant effects of the derivatives were evaluated by DPPH and H2O2 scavenging methods. The derivatives were screened for hMAO-A and hMAO-B inhibition through a series […]

Continue reading »

Heart patients need kindness as much as medical intervention

Heart attack patients can suffer substantial emotional trauma once the medics have finished making their bodies better, according to new research. The emotional whiplash can range from phobia about moving in case their heart rate rises, to difficulty accepting a new identity as someone with a serious health condition. The study found emotional trauma following a heart attack was more […]

Continue reading »

If someone hurt you this year, forgiving them may improve your health (as long as you’re safe, too)

During the end-of-year holidays families often come together to exchange gifts and, sometimes, to confront long-held grudges. What better gift than a peace offering? Conflict is rarely pleasant and arguments in families can be particularly upsetting. We all know that knot in the pit of the stomach, the flushed face and sweaty hands we experience when we feel we have […]

Continue reading »

Depression, anxiety may take same toll on health as smoking and obesity

An annual physical typically involves a weight check and questions about unhealthy habits like smoking, but a new study from UC San Francisco suggests health care providers may be overlooking a critical question: Are you depressed or anxious? Anxiety and depression may be leading predictors of conditions ranging from heart disease and high blood pressure to arthritis, headaches, back pain […]

Continue reading »

Major data release set for early 2019 as recruitment wraps up for nation’s largest adolescent brain study

Research teams all across the globe are eagerly awaiting a major release of data from the largest study ever attempted on the adolescent brain. FIU is one of 21 sites studying nearly 11,874 participants collectively, including 2,100 twins or triplets. Researchers will follow the children, currently between the ages of 9 and 10, through young adulthood. Recruitment for participants wrapped […]

Continue reading »

Healthy blood stem cells have as many DNA mutations as leukemic cells

Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ. Rather, the location of DNA mutations is relevant. Using the mutation patterns in hematopoietic stem and progenitor cells (HSPCs), the team was able to trace the developmental lineage tree of the cells. Van Boxtel, […]

Continue reading »

Radiation/cisplatin combination established as standard of care for HPV+ oral cancer

Combinations of radiation and chemotherapy drugs have been shown to cure HPV-related head and neck cancer with a high success rate. A new phase III trial has now determined that cisplatin chemotherapy, combined with radiation therapy, produces the best results and should be considered the standard of care. Findings will be presented today at the 60th Annual Meeting of the […]

Continue reading »

As stem cell and gene technologies advance, La Jolla conference mushrooms

In 2006, a few hundred mostly local researchers gathered in La Jolla to discuss the emerging but still science-fictiony field of stem cells. Since then, stem cells, enhanced by gene therapy, have progressed to yield breakthrough treatments, most spectacularly in cancer. Likewise, the conference known as the Cell & Gene Meeting on the Mesa has mushroomed into an international event. […]

Continue reading »
1 2 3 4 5 6