New technique makes heart valve replacement safer for some high-risk patients

Scientists have developed a novel technique that prevents coronary artery obstruction during transcatheter aortic valve replacement (TAVR), a rare but often fatal complication. The method, called Bioprosthetic Aortic Scallop Intentional Laceration to prevent Iatrogenic Coronary Artery obstruction (BASILICA), will increase treatment options for high-risk patients who need heart valve procedures. The findings by researchers at the National Institutes of Health […]

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Sulfur amino acid restriction could amount to new dietary approach to health

The longevity and health improvements seen in animals on sulfur amino acid-restricted diets could translate to people, according to Penn State College of Medicine researchers who recently conducted a review of published studies. More research is needed to confirm the benefits in people, the scientists said. Amino acids are the building blocks of all proteins in the body. A subcategory […]

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ACA has provided better access to care for cancer survivors

(HealthDay)—Cancer survivors are more likely to have difficulty accessing and affording health care, but the proportion reporting these issues is decreasing, according to a study published online March 29 in JAMA Oncology. Ryan D. Nipp, M.D., M.P.H., from Massachusetts General Hospital and Harvard Medical School in Boston, and colleagues used data from the National Health Interview Survey to examine health […]

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Adult-onset neurodegeneration has roots in early development

The disease mechanism for adult-onset progressive degenerative diseases begins much earlier than previously thought, according to a Northwestern Medicine study published in the Journal of Clinical Investigation. Using a mouse model of spinocerebellar ataxia type 1 (SCA1) genetically engineered to precisely mirror the human disease, a team of investigators showed that there is an altered neural circuitry in the cerebellum […]

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Researchers define target and mechanism of antibacterial drug fidaxomicin (Dificid)

A team of Rutgers University and international scientists has determined the molecular target and mechanism of the antibacterial drug fidaxomicin (trade name Dificid). Fidaxomicin was approved in 2011 for treatment of the CDC “urgent threat” bacterial pathogen Clostridium difficile (C. diff) and currently is one of two front-line drugs for treatment of C. diff. Fidaxomicin also exhibits potent antibacterial activity […]

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Slow, steady waves keep brain humming

If you keep a close eye on an MRI scan of the brain, you’ll see a wave pass through the entire brain like a heartbeat once every few seconds. This ultra-slow rhythm was recognized decades ago, but no one quite knew what to make of it. MRI data are inherently noisy, so most researchers simply ignored the ultra-slow waves. But […]

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Researchers find alternate path for Listeria to sicken people

Purdue University scientists have found another pathway that Listeria uses to enter the bloodstream, suggesting that forms of the foodborne bacteria considered benign may be more dangerous than once thought. About 600 million people around the world contract listeriosis each year, with 420,000 dying, according to the World Health Organization. In the U.S., 1,600 people are infected each year, causing […]

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Relapse in major depression linked to brain cortical changes

(HealthDay)—For patients with major depressive disorder (MDD), relapse is associated with brain cortical changes over two years, according to a study published online March 28 in JAMA Psychiatry. Dario Zaremba, from the University of Münster in Germany, and colleagues conducted a longitudinal case-control study involving patients with acute MDD at baseline and healthy controls. Participants were subdivided into groups with […]

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