‘Killer’ kidney cancers identified by studying their evolution

Scientists have discovered that kidney cancer follows distinct evolutionary paths, enabling them to detect whether a tumour will be aggressive and revealing that the first seeds of kidney cancer are sown as early as childhood. The three Cancer Research UK funded studies, published in the journal Cell, shed light on the fundamental principles of cancer evolution and could lead to […]

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Understanding how leukemia and lymphoma cells resist treatment

In a study published in Nature Communications, a team led IRCM Hematopoiesis and Cancer Research Unit director Tarik Möröy reveals how the GFI1 protein sometimes helps leukemia and lymphoma cancer cells evade therapy. This discovery could eventually help orient patients towards more effective treatment by considering the particular characteristics of their disease. In this Q&A, Möröy and his team offer […]

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Anti-epileptic drugs increase the risk of bone fractures in children

New research has shown evidence that anti-epileptic drugs (AEDs) reduce bone density in children and therefore lead to an increase in the number of fractures, if used for more than a year. The study by the Murdoch Children’s Research Institute (MCRI), in conjunction with the Royal Melbourne Hospital (RMH), has prompted experts to highlight the importance of considering side effects […]

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New insight into widespread virus behind birth defects

A Northwestern Medicine study published in Developmental Cell provides new insights into how cytomegalovirus—a common virus in the herpes family—replicates within human cells, and identifies proteins that may be therapeutically targeted to suppress infection. Human cytomegalovirus (HCMV) is widespread around the world, infecting between 60 to 100 percent of all adults. There is currently no cure or vaccine for HCMV; […]

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Mouse study links early metastasis to systemic inflammation caused by wound healing

According to new research conducted in mice by Whitehead Institute scientists, surgery in breast cancer patients, which while often curative, may trigger a systemic immunosuppressive response, allowing the outgrowth of dormant cancer cells at distant sites whose ability to generate tumors had previously been kept in check by the immune system. Taking a non-steroidal anti-inflammatory drug (NSAID) around the time […]

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Evaluating pediatric leukemia treatment

A drug called dasatinib was found to be safe and effective for children with chronic myeloid leukemia, according to a clinical trial published in the Journal of Clinical Oncology. Based on the findings, the drug has been approved by the FDA and is now available for use in some pediatric patients. The study was co-authored by Nobuko Hijiya, MD, professor […]

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Teachers can help reduce mental health problems in children, study finds

School-based mental health services delivered by teachers and staff can significantly reduce mental health problems in elementary-aged children, according to a new study by researchers at the Florida International University Center for Children and Families. The implications are significant considering approximately 30 to 40 percent of youth in the U.S. will be diagnosed with at least one mental health disorder […]

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Study may show how chronic early-life stress raises PTSD vulnerability

A collaboration between investigators at Massachusetts General Hospital and Khyber Medical University in Pakistan may have discovered how chronic stress experienced early in life increases vulnerability to post-traumatic stress disorder (PTSD) later in life. In their report published in Translational Psychiatry the researchers describe finding that chronic stress induces a persistent increase in the hormone ghrelin, both in a rat […]

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Mental disorders among leading causes of illness in children worldwide

While global rates of mental disorders in children have remained stable over time, the decline of infectious diseases will place mental disorders among the main causes of disease in children aged 4-15 years, according to a study published in the open access journal Child and Adolescent Psychiatry and Mental Health. Marie-Laure Baranne and Bruno Falissard at INSERM, France described the […]

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