PARP-1 may be key to effectiveness of PARP inhibitors, and now researchers can image it

Penn Medicine researchers have used CRISPR/Cas9 gene editing technology to isolate a key genetic feature that could cause resistance to PARP inhibitors in patients with ovarian cancer—and they’ve also proven they have a way to see that feature using PET imaging. The team found PARP inhibitors—a type of targeted therapy that kills cancer cells with mutations in their DNA repair […]

Continue reading »

Largest-ever study of thyroid cancer genetics finds new mutations, suggests immunotherapy

University of Colorado Cancer Center researchers recently completed the largest-ever study of thyroid cancer genetics, mining the data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers. In addition to identification of specific genes that may drive these cancers and thus provide attractive targets for treatment, the researchers found that in several samples of advanced […]

Continue reading »

Noninvasive brain tumor biopsy on the horizon

Taking a biopsy of a brain tumor is a complicated and invasive surgical process, but a team of researchers at Washington University in St. Louis is developing a way that allows them to detect tumor biomarkers through a simple blood test. Hong Chen, a biomedical engineer, and Eric C. Leuthardt, MD, a neurosurgeon, led a team of engineers, physicians and […]

Continue reading »

Noninvasive spinal stimulation method enables paralyzed people to regain use of hands, study finds

The ability to perform simple daily tasks can make a big difference in people’s lives, especially for those with spinal cord injuries. A UCLA-led team of scientists reports that six people with severe spinal cord injuries—three of them completely paralyzed—have regained use of their hands and fingers for the first time in years after undergoing a nonsurgical, noninvasive spinal stimulation […]

Continue reading »

Common class of drugs linked to dementia even when taken 20 years before diagnosis

The largest and most detailed study of the long-term impact of anticholinergic drugs, a class of drugs commonly prescribed in the United States and United Kingdom as antidepressants and incontinence medications, has found that their use is associated with increased risk of dementia, even when taken 20 years before diagnosis of cognitive impairment. An international research team from the US, […]

Continue reading »

Preventive use of common antibiotic reduces child mortality in sub-Saharan Africa

Treating young children in Sub-Saharan Africa with azithromycin, a safe, inexpensive, and widely used antibiotic, significantly reduced deaths of children under five in a large randomized trial led by scientists at UC San Francisco. The finding could help speed progress toward the United Nations’ goal of ending preventable child deaths by 2030. Researchers randomized 1,533 communities in Niger, Malawi, and […]

Continue reading »

Study shows a new approach to treating patients with stage IV Wilms tumor

A new study showing significantly improved survival rates for patients with stage IV Wilms tumors with lung metastases was recently published in the Journal of Clinical Oncology. The outcomes of the study, “Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children’s Oncology Group AREN0533 Study”, will be a game-changer in treating Wilms tumor […]

Continue reading »

Don’t panic over ‘dry drowning’ reports, ER docs say

(HealthDay)—Despite media hype this week around what’s being called “dry drowning,” a group representing U.S. emergency physicians says the water is still safe for kids this summer. Reports of so-called dry drowning have made headlines, and just this week the family of 4-year-old Elianna Grace of Sarasota, Fla., sounded the alarm that she had almost died from the condition. According […]

Continue reading »

Study shows drug effectiveness in reducing glucocorticoid-induced bone loss

About one in every 100 people in the world takes glucocorticoids long term to treat immune-mediated diseases. However, glucocorticoids, such as prednisone, have a side effect—they induce the bone loss called osteoporosis, causing an estimated yearly bone fracture rate of 5 percent. An alternative treatment option now appears promising, according to results of an international study published in the journal […]

Continue reading »
1 178 179 180 181 182 201