Protection against malaria: A matter of balance

A balanced production of pro and anti-inflammatory cytokines at two years of age protects against clinical malaria in early childhood, according to a study led by the Barcelona Institute for Global Health (ISGlobal). The results also indicate that early exposure to the parasite does not affect the risk of developing the disease, although it could affect the parasite-specific immune response later in life.

Malaria particularly affects children under five years of age, who need to develop effective immunity against the most severe forms of the disease. Certain parasite-specific antibodies are known to protect, but little is known about the protective role of mediators (cytokines) produced by cells of the immune system. Furthermore, it is not clear whether the timing of first parasite exposure during infancy affects the secretion of such cytokines.

In this study, Carlota Dobaño and her team evaluated whether the cytokines produced in the first two years after birth affect the risk of subsequent malaria. They also analysed whether the timing of parasite exposure alters the cytokine response. The study included over 300 newborns from Magrara, a village in Southern Mozambique, some of whom received preventive malaria treatment during their first year of life. Cytokine production by blood cells was measured at different points during the first two years, and the participants were followed up for clinical malaria until four years of age.

The results show that a pro-inflammatory signature (IL-1, IL-6 and TNF cytokines) followed by an anti-inflammatory (IL-10 cytokine) signature between the first and second year of life is associated with a lower risk of clinical malaria between ages three and four. “This makes sense, since IL-10 suppresses excessive inflammation,” explains Dobaño.

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