How manganese produces a parkinsonian syndrome

Using X-ray fluorescence at synchrotrons DESY and ESRF, researchers in the Centre d’Etudes Nucléaires de Bordeaux Gradignan (CNRS/Université de Bordeaux) have demonstrated the consequences of a mutation responsible for a hereditary parkinsonian syndrome: accumulated manganese in the cells appears to disturb protein transport. This work, carried out with colleagues at the University of Texas at Austin (USA), was published in […]

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Developing a better, faster diagnostic for cryptosporidiosis

Cryptosporidiosis is the leading cause of waterborne diseases among humans in the United States, infecting almost 750,000 people each year, according to the Centers for Disease Control and Prevention. Globally in 2010, nearly 100,000 cases were fatal. The disease is of particular interest to Dr. Michael Riggs, a veterinarian and professor in the Department of Animal and Comparative Biomedical Sciences […]

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Mosquito known to transmit malaria has been detected in Ethiopia for the first time

A type of mosquito that transmits malaria has been detected in Ethiopia for the first time, and the discovery has implications for putting more people at risk for malaria in new regions, according to a study led by a Baylor University researcher. The mosquito, Anopheles stephensi, normally is found in the Middle East, Indian Subcontinent and China. Previous research shows […]

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Scientists make strides in creation of clinical-grade bone

A team of scientists from the New York Stem Cell Foundation (NYSCF) Research Institute reported Friday in Stem Cell Research and Therapy that they have made valuable progress toward creating clinical-grade cells for treatment of bone disease and injury. In their study, the team identified two types of growth media that could support effective expansion of mesenchymal progenitor (MP) cells […]

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Protective effects of ADM-RAMP2 system make it a new therapeutic target for retinal vein occlusion

A clot in the retinal vein can lead to severe and irreversible loss of vision. In a report in the American Journal of Pathology investigators utilize a newly developed model of central retinal vein occlusion (CRVO) in mice that mimics many of the clinical features of CRVO in humans to study the pathologic effects of retinal occlusion and demonstrate the […]

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Vyndaqel

January 14, 2019 – Pfizer Inc. (NYSE: PFE) announced today that the US Food and Drug Administration (FDA) accepted for filing the company’s New Drug Applications (NDAs) for tafamidis for the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM). Pfizer has submitted two NDAs based on two forms of tafamidis: meglumine salt and free acid. Tafamidis is the only product to complete […]

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